Table 1.
CpG sites associated with phenotypes in either MWAS 1 or MWAS 2
| Phenotype | CpG site | Chr | BP position | Annotated Gene | MWAS 1 | MWAS 2 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Effect size | Standard error | P-value | Effect size | Standard error | P-value | |||||
| Preterm birth | cg00725333 | 3 | 64 189 256 | PRICKLE2 | −0.2747 | 0.0376 | 6.24 × 10 −13 | −0.0364 | 0.0060 | 1.15 × 10 −9 |
| cg17668848 | 3 | 108 029 973 | HHLA2 | −0.2871 | 0.0396 | 9.13 × 10 −13 | −0.0356 | 0.0058 | 8.21 × 10 −10 | |
| cg24329141 | 10 | 27 095 369 | ABI1 | −0.2368 | 0.0352 | 2.98 × 10 −11 | −0.0345 | 0.0057 | 1.27 × 10 −9 | |
| Low birth weight | cg15582176 | 1 | 1 183 528 | C1QTNF12 | −0.3604 | 0.0661 | 6.53 × 10 −8 | −0.0254 | 0.0054 | 2.49 × 10−6 |
| cg19909717 | 6 | 107 924 415 | SOBP | −0.2225 | 0.0403 | 4.35 × 10 −8 | −0.0329 | 0.0055 | 1.59 × 10 −9 | |
| cg21803443 | 7 | 126 547 786 | GRM8 | −0.3656 | 0.0618 | 4.62 × 10 −9 | −0.0278 | 0.0056 | 7.22 × 10−7 | |
| cg12090821 | 14 | 21 755 658 | RPGRIP1 | −0.0857 | 0.0152 | 2.43 × 10 −8 | −0.0329 | 0.0058 | 1.47 × 10 −8 | |
| cg05905731 | 16 | 85 485 785 | −0.1695 | 0.0300 | 2.23 × 10 −8 | −0.0294 | 0.0055 | 7.50 × 10−8 | ||
| Young parent | cg00528572 | 11 | 92 703 433 | MTNR1B | −0.1369 | 0.0200 | 9.04 × 10 −12 | −0.0145 | 0.0025 | 4.47 × 10 −9 |
| cg02427109 | 18 | 77 917 459 | PARD6G, PARD6G-AS1 | −0.1163 | 0.0213 | 4.96 × 10 −8 | −0.0101 | 0.0025 | 4.12 × 10−5 | |
| Population density | cg06759845 | 1 | 156 460 474 | MEF2D | 5.20 × 10−6 | 9.40 × 10−7 | 3.40 × 10 −8 | 90.39 | 17.02 | 1.10 × 10−7 |
| cg12433043 | 6 | 100 619 893 | −6.65 × 10−6 | 1.20 × 10−6 | 3.37 × 10 −8 | −88.86 | 16.75 | 1.13 × 10−7 | ||
| cg03623878 | 13 | 113 655 560 | MCF2L | 9.10 × 10−6 | 1.58 × 10−6 | 9.56 × 10 −9 | 81.18 | 16.88 | 1.51 × 10−6 | |
| cg08036492 | 17 | 13 976 536 | COX10 | 3.09 × 10−6 | 5.71 × 10−7 | 6.74 × 10 −8 | 87.75 | 18.29 | 1.61 × 10−6 | |
| MDD | cg02280719 | 1 | 6 802 222 | 0.0400 | 0.0064 | 5.99 × 10 −10 | 0.0174 | 0.0043 | 5.32 × 10−5 | |
| cg08548783 | 6 | 57 903 690 | 0.0378 | 0.0067 | 1.37 × 10 −8 | 0.0142 | 0.0043 | 9.79 × 10−4 | ||
Note: MWAS 1 results are from a methylome-wide association analysis using linear regression and MWAS 2 results are from a methylome-wide association analysis using OSCA. Bold P-values indicate an association after correction for multiple testing (P < 7.01 × 10−8). Sites are ordered by phenotype and then genomic position. Chromosome number (Chr) and base pair (BP) position are based on genome assembly GRCh37 (hg19). Annotation of genes is provided by missMethyl.