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. 2021 Sep 11;31(4):510–522. doi: 10.1093/hmg/ddab235

Figure 5.

Figure 5

Overexpression of GNAO1 G42R in two populations of striatal neurons impairs locomotor behaviors in mice. (A) Schematic showing adeno-associated viral (AAV) particle delivery and overexpression of wt or G42R Gαo in two striatal neuron populations, dMSN and iMSN. (B) Quantitation of hindlimb clasping which indicates increased dystonia. (C) Quantitation of limb coordination based on latency to fall in backward walking test. (D, E & F) Quantitation of three motor coordination and balance tests (D) ledge test, (E) vertical pole test and (F) horizontal pole test. Comparisons represent two-tailed unpaired Student’s t-test. n = 7 animals per genotype. Error bars are SEM. ***P < 0.001.