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. 2022 Feb 15;2022:4217593. doi: 10.1155/2022/4217593

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Copyright © 2022 Teng Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Potential neural circuits underlying the comorbidity of chronic pain and anxiety. ACC: anterior cingulate cortex; BLA: basolateral amygdala; BNST: bed nucleus of the stria terminalis; CeA: central amygdala; DRN: dorsal raphe nucleus; HPC: hippocampus; LH: lateral hypothalamus; LHb: lateral habenula; LS: lateral septum; mPFC: medial prefrontal cortex; MS: medial septum; NAc: nucleus accumbens; PAG: periaqueductal gray; PB: parabrachial nucleus; RVM: rostromedial ventral medulla; TH: thalamus; VTA: ventral tegmental area. ?, not confirmed for chronic pain-related anxiety.