Figure 1.

A brief schematic overview of prediction and the application of neoantigen and the application of neoantigen-based vaccines and ACT. Collect biological materials (tumor tissues) from patients with colorectal cancer. Predict, identify, and screen tumor neoantigens. The selected neoantigens are made into vaccines, or corresponding T-cells are expanded for patient treatment. Neoantigen vaccines or ACT can be used in combination with adjuvants, chemotherapy, radiotherapy, and/or immune checkpoint inhibitor.