Table 3.
IRR (95% CI) for individual outcomes in predefined risk periods immediately before and after exposure to vaccination and before and after a positive SARS-CoV-2 test result, adjusted for calendar time from 1 December 2020 to 24 August 2021 (cells with an asterisk are suppressed). n/a, not applicable; pyrs, person-years
| ChAdOx1nCoV-19 vaccine | BNT162b2 mRNA vaccine | mRNA-1273 vaccine | Positive SARS-CoV-2 test | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Events | pyrs | IRR (95% CI) | Events | pyrs | IRR (95% CI) | Events | pyrs | IRR (95% CI) | Events | pyrs | IRR (95% CI) | |
| Myocarditis | ||||||||||||
| Baseline | 550 | 409.0 | 1.00 | 398 | 307.7 | 1.00 | 22 | 20.4 | 1.00 | 119 | 216.7 | 1.00 |
| −28 to −1 days: first dose/positive test | 81 | 70.4 | 0.74 (0.58, 0.95) | 49 | 49.0 | 0.75 (0.55, 1.01) | * | * | 0.41 (0.09, 1.87) | 32 | 21.0 | 2.84 (1.89, 4.28) |
| Day 0: first dose/positive test | * | * | 0.54 (0.14, 2.19) | * | * | 1.24 (0.40, 3.88) | * | * | n/a | 36 | 0.8 | 78.21 (52.90, 115.62) |
| 1–7 days: first dose/positive test | 47 | 17.6 | 1.76 (1.29, 2.42) | 27 | 12.5 | 1.45 (0.97, 2.17) | 7 | 0.7 | 8.38 (3.53, 19.91) | 68 | 5.8 | 21.08 (15.34, 28.96) |
| 8–14 days: first dose/positive test | 35 | 17.6 | 1.22 (0.85, 1.74) | 23 | 12.5 | 1.23 (0.80, 1.90) | * | * | n/a | 37 | 5.9 | 11.29 (7.70, 16.57) |
| 15–21 days: first dose/positive test | 30 | 17.6 | 1.03 (0.71, 1.51) | 21 | 12.4 | 1.14 (0.73, 1.78) | * | * | n/a | 18 | 6.0 | 5.36 (3.24, 8.89) |
| 22–28 days: first dose/positive test | 30 | 17.5 | 1.03 (0.71, 1.51) | 23 | 12.0 | 1.33 (0.86, 2.04) | * | * | n/a | 11 | 6.1 | 3.08 (1.65, 5.75) |
| −28 to −1 days: second dose | 58 | 58.3 | 0.65 (0.49, 0.87) | 48 | 33.3 | 0.96 (0.70, 1.32) | * | * | 2.19 (0.45, 10.69) | |||
| Day 0: second dose | * | * | 0.64 (0.16, 2.56) | * | * | n/a | * | * | n/a | |||
| 1–7 days: second dose | 13 | 14.8 | 0.60 (0.34, 1.04) | 23 | 9.3 | 1.75 (1.13, 2.70) | * | * | 23.10 (6.46, 82.56) | |||
| 8–14 days: second dose | 28 | 14.8 | 1.31 (0.88, 1.93) | 15 | 9.3 | 1.16 (0.69, 1.97) | * | * | n/a | |||
| 15–21 days: second dose | 19 | 14.8 | 0.91 (0.57, 1.45) | 14 | 9.3 | 1.14 (0.66, 1.97) | * | * | n/a | |||
| 22–28 days: second dose | 24 | 14.8 | 1.16 (0.76, 1.76) | 12 | 9.1 | 1.01 (0.57, 1.82) | * | * | n/a | |||
| 1–28 days: first dose/positive test | 142 | 70.2 | 1.29 (1.05, 1.58) | 94 | 49.4 | 1.31 (1.03, 1.66) | 9 | 2.9 | 2.97 (1.34, 6.58) | 134 | 23.9 | 9.76 (7.51, 12.69) |
| 1–28 days: second dose | 84 | 59.2 | 1.00 (0.78, 1.27) | 64 | 37.1 | 1.30 (0.98, 1.72) | * | * | 9.84 (2.69, 36.03) | |||
| Pericarditis | ||||||||||||
| Baseline | 581 | 405.2 | 1.00 | 414 | 285.9 | 1.00 | 12 | 11.2 | 1.00 | 95 | 115.4 | 1.00 |
| −28 to −1 days: first dose/positive test | 64 | 70.7 | 0.54 (0.42, 0.71) | 42 | 47.2 | 0.63 (0.45, 0.87) | * | * | 1.62 (0.52, 5.07) | 29 | 10.0 | 3.57 (2.30, 5.55) |
| Day 0: first dose/positive test | * | * | n/a | * | * | 0.74 (0.18, 2.98) | * | * | n/a | 11 | 0.4 | 35.04 (18.47, 66.46) |
| 1–7 days: first dose/positive test | 19 | 17.7 | 0.59 (0.37, 0.94) | 11 | 12.0 | 0.59 (0.32, 1.07) | * | * | n/a | 11 | 2.8 | 4.85 (2.56, 9.18) |
| 8–14 days: first dose/positive test | 34 | 17.7 | 1.00 (0.70, 1.44) | 9 | 12.0 | 0.46 (0.24, 0.90) | * | * | n/a | 9 | 2.9 | 3.81 (1.90, 7.63) |
| 15–21 days: first dose/positive test | 23 | 17.6 | 0.64 (0.42, 0.99) | 19 | 11.9 | 0.98 (0.62, 1.57) | * | * | n/a | * | * | 1.63 (0.59, 4.45) |
| 22–28 days: first dose/positive test | 26 | 17.6 | 0.71 (0.47, 1.06) | 20 | 11.6 | 1.02 (0.65, 1.61) | * | * | n/a | * | * | 1.15 (0.36, 3.66) |
| −28 to −1 days: second dose | 58 | 61.0 | 0.43 (0.32, 0.57) | 35 | 36.5 | 0.47 (0.33, 0.67) | * | * | n/a | |||
| Day 0: second dose | * | * | n/a | * | * | 0.99 (0.32, 3.09) | * | * | n/a | |||
| 1–7 days: second dose | 37 | 15.6 | 1.12 (0.79, 1.58) | 12 | 10.1 | 0.58 (0.33, 1.04) | * | * | n/a | |||
| 8–14 days: second dose | 29 | 15.6 | 0.89 (0.61, 1.31) | 16 | 10.1 | 0.80 (0.48, 1.32) | * | * | n/a | |||
| 15–21 days: second dose | 36 | 15.6 | 1.13 (0.80, 1.60) | 21 | 10.1 | 1.05 (0.67, 1.64) | * | * | n/a | |||
| 22–28 days: second dose | 15 | 15.5 | 0.49 (0.29, 0.82) | 26 | 10.1 | 1.34 (0.89, 2.02) | * | * | n/a | |||
| 1–28 days: first dose/positive test | 102 | 70.6 | 0.74 (0.59, 0.92) | 59 | 47.4 | 0.77 (0.58, 1.02) | * | * | 1.64 (0.45, 5.94) | 27 | 11.7 | 2.79 (1.80, 4.32) |
| 1–28 days: second dose | 117 | 62.4 | 0.91 (0.73, 1.13) | 75 | 40.4 | 0.93 (0.72, 1.21) | * | * | n/a | |||
| Cardiac arrhythmia | ||||||||||||
| Baseline | 118,356 | 88,084.1 | 1.00 | 113,968 | 81,778.6 | 1.00 | 1,221 | 867.6 | 1.00 | 15,119 | 24,323.4 | 1.00 |
| −28 to −1 days: first dose/positive test | 17,562 | 15,500.4 | 0.78 (0.76, 0.79) | 12,767 | 13,158.8 | 0.72 (0.70, 0.73) | 184 | 126.8 | 0.90 (0.77, 1.05) | 6,618 | 2,223.6 | 4.82 (4.68, 4.97) |
| Day 0: first dose/positive test | 289 | 553.9 | 0.33 (0.30, 0.38) | 232 | 497.0 | 0.33 (0.29, 0.37) | 9 | 4.5 | 1.32 (0.69, 2.54) | 3,847 | 86.7 | 69.83 (67.32, 72.43) |
| 1–7 days: first dose/positive test | 5,873 | 3,872.1 | 0.95 (0.92, 0.97) | 3,958 | 3,471.4 | 0.79 (0.76, 0.81) | 38 | 31.6 | 0.80 (0.58, 1.11) | 4,593 | 613.3 | 11.73 (11.33, 12.14) |
| 8–14 days: first dose/positive test | 5,981 | 3,867.0 | 0.93 (0.90, 0.95) | 4,837 | 3,458.9 | 0.92 (0.89, 0.95) | 40 | 31.4 | 0.88 (0.64, 1.21) | 2,643 | 624.7 | 6.57 (6.30, 6.85) |
| 15–21 days: first dose/positive test | 6,243 | 3,863.0 | 0.95 (0.92, 0.97) | 4,971 | 3,404.5 | 0.92 (0.90, 0.95) | 43 | 32.1 | 1.02 (0.75, 1.38) | 966 | 638.8 | 2.30 (2.15, 2.45) |
| 22–28 days: first dose/positive test | 6,128 | 3,857.0 | 0.92 (0.89, 0.94) | 4,593 | 3,150.5 | 0.89 (0.86, 0.91) | 35 | 29.1 | 0.90 (0.64, 1.26) | 738 | 653.8 | 1.67 (1.55, 1.80) |
| −28 to −1 days: second dose | 18,595 | 13,728.4 | 0.75 (0.74, 0.77) | 15,010 | 10,907.1 | 0.75 (0.74, 0.77) | 38 | 43.2 | 0.66 (0.47, 0.92) | |||
| Day 0: second dose | 265 | 502.4 | 0.30 (0.26, 0.33) | 257 | 444.6 | 0.32 (0.29, 0.37) | * | * | n/a | |||
| 1–7 days: second dose | 5,236 | 3,517.4 | 0.84 (0.82, 0.87) | 4,737 | 3,112.3 | 0.85 (0.83, 0.88) | 22 | 11.2 | 1.93 (1.25, 2.96) | |||
| 8–14 days: second dose | 5,931 | 3,517.4 | 0.97 (0.94, 0.99) | 5,288 | 3,112.3 | 0.95 (0.92, 0.98) | 13 | 11.2 | 1.39 (0.80, 2.42) | |||
| 15–21 days: second dose | 6,019 | 3,517.4 | 1.00 (0.97, 1.03) | 5,495 | 3,112.3 | 0.99 (0.96, 1.02) | 6 | 11.2 | 0.84 (0.37, 1.89) | |||
| 22–28 days: second dose | 5,833 | 3,510.8 | 0.99 (0.97, 1.02) | 5,427 | 3,098.4 | 0.99 (0.96, 1.02) | 7 | 9.8 | 1.43 (0.67, 3.03) | |||
| 1–28 days: first dose/positive test | 24,225 | 15,459.0 | 0.94 (0.93, 0.96) | 18,359 | 13,485.4 | 0.89 (0.87, 0.90) | 156 | 124.1 | 0.90 (0.76, 1.06) | 8,940 | 2,530.5 | 5.35 (5.21, 5.50) |
| 1–28 days: second dose | 23,019 | 14,063.1 | 0.95 (0.94, 0.96) | 20,947 | 12,435.3 | 0.95 (0.93, 0.96) | 48 | 43.4 | 1.46 (1.08, 1.98) | |||