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. 2022 Feb 9;13:795777. doi: 10.3389/fmicb.2022.795777

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Copyright © 2022 Liu, Li, Qi, Wen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spearman correlation analysis between bacteria and function among the four groups. We selected bacteria that significantly increased or decreased during the progression of OSCC and analyzed the correlation between KEGG pathways, virulence genes, and virulence factors. (A) Correlation analysis between bacteria and KEGG pathways. F. nucleatum, C. sputigena, P. endodontalis, and G. haemolysans showed a significant positive correlation with bacterial chemotaxis and flagellar assembly. (B) Correlation analysis between bacteria and virulence genes. The pathogens F. nucleatum showed a significant positive correlation with the algR, flhF, ompA, lpxD, and ybtP genes. (C) Correlation analysis between bacteria and virulence factors. P. endodontalis and Pse5Ac7Ac, O-antigen showed a significant positive correlation with Pse5Ac7Ac and O-antigen. (using Kruskal-Wallis non-parametric tests,*p < 0.05, **p < 0.01).