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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Crit Care Med. 2022 Mar 1;50(3):e284–e293. doi: 10.1097/CCM.0000000000005333

Table 1.

Subject Characteristics

Characteristic Discovery Validation
Genotyped (n=1589) Genotyped (n=863)
Patient Age, mean ± SD 58 (±17) 55 (±16)
Male patients, n (%) 928 (58) 543 (63)
Caucasian, n (%) 1589 (100) 863 (100)
Source of critical illness, n (%)
 Sepsis 1201 (76) 612 (71)
 Trauma 110 (7) 0
 Other 278 (17) 251 (29)
APACHE III score, mean ± SD 78 (±27) 65 (±25)
Comorbidities, n (%)
 Diabetes 381 (24) 228 (26)
 Cirrhosis 74 (5) 90 (10)
 End Stage Renal Disease 73 (5) 22 (3)
ARDS, n (%) 1022 (64) 231 (27)
SOFA, mean ± SD 5.2 (±2.8) 2.7 (±2.6)
Plasma sFas (pg/mL), mean ± SD 11082 (±7265) 13419 (±7670)
Mortality, n (%) 281 (18) 120 (14)