Table 1.
The 17 novel blood pressure (BP) loci identified by pleiotropic analysis
| SNP | CHR | BP | UKB‐ICBP | UKB‐ICBP | UKB‐ICBP | UKB‐ICBP | MVP | UKB‐ICBP–MVP | Genes |
|---|---|---|---|---|---|---|---|---|---|
| P_SBP | P_DBP | P_PP | p pleio a | p pleio a | p pleio a | ||||
| rs11162906 | 1 | 80500074 | 3.19 × 10−2 | 1.75 × 10−2 | 1.78 × 10−6 | 2.41 × 10−9 | 1.53 × 10−3 | 3.54 × 10−11 | AC098657.2 |
| rs17713879 | 2 | 254215 | 5.19 × 10−2 | 2.66 × 10−2 | 2.05 × 10−5 | 3.75 × 10−8 | 8.92 × 10−4 | 1.35 × 10−10 | SH3YL1 |
| rs3136302 | 2 | 48021379 | 4.08 × 10−1 | 5.84 × 10−5 | 9.62 × 10−6 | 2.96E−11 | 4.48 × 10−2 | 8.30 × 10−12 | MSH6 |
| rs6735304 | 2 | 101617631 | 4.18 × 10−2 | 2.38 × 10−2 | 1.43 × 10−6 | 1.47 × 10−8 | 6.21 × 10−4 | 6.36 × 10−11 | RPL31/TBC1D8 |
| rs12470661 | 2 | 232060050 | 5.09 × 10−2 | 3.07 × 10−3 | 6.68 × 10−7 | 5.33 × 10−11 | 1.97 × 10−4 | 4.55 × 10−14 | HTR2B/ARMC9 |
| rs10947978 | 6 | 41471608 | 7.01 × 10−1 | 9.89 × 10−6 | 1.44 × 10−5 | 2.65 × 10−11 | 1.84 × 10−2 | 3.26 × 10−12 | LINC01276 |
| rs56098119 | 6 | 90296727 | 7.63 × 10−2 | 1.38 × 10−2 | 6.81 × 10−6 | 1.69 × 10−8 | 2.89 × 10−2 | 1.77 × 10−9 | ANKRD6 |
| rs150953973 | 6 | 120780033 | 2.98 × 10−1 | 9.7 × 10−4 | 4.01 × 10−6 | 3.54 × 10−9 | 1.64 × 10−2 | 1.85 × 10−10 | RNU6‐214P |
| rs180271 | 7 | 93539479 | 6.11 × 10−1 | 1.72 × 10−4 | 2.63 × 10−5 | 3.69 × 10−9 | 2.05 × 10−3 | 2.92 × 10−11 | GNGT1 |
| rs11989271 | 8 | 122632611 | 1.51 × 10−1 | 8.47 × 10−4 | 7.80 × 10−7 | 1.14 × 10−10 | 9.37 × 10−3 | 1.38 × 10−11 | HAS2 |
| rs10868842 | 9 | 73119085 | 1.57 × 10−1 | 3.58 × 10−4 | 9.71 × 10−6 | 1.37 × 10−11 | 4.07 × 10−3 | 2.54 × 10−13 | LINC00583 |
| rs12768143 | 10 | 22808844 | 3.92 × 10−2 | 5.03 × 10−3 | 8.61 × 10−8 | 9.18 × 10−11 | 1.58 × 10−2 | 2.39 × 10−11 | PIP4K2A |
| rs1343676 | 12 | 33537387 | 7.19 × 10−1 | 2.03 × 10−7 | 8.65 × 10−7 | 9.56 × 10−15 | 4.04;× 10−4 | 3.04 × 10−16 | SYT10 |
| rs7322054 | 13 | 38246708 | 6.71 × 10−1 | 1.99 × 10−7 | 7.76 × 10−4 | 1.04 × 10−11 | 1.01 × 10−2 | 5.86 × 10−13 | TRPC4 |
| rs61972411 | 13 | 100602630 | 2.8 2× 10−4 | 6.59 × 10−1 | 1.87 × 10−7 | 1.45 × 10−8 | 1.89 × 10−2 | 2.23 × 10−9 | LOC101927437 |
| rs62621400 | 15 | 101718239 | 2.25 × 10−1 | 1.70 × 10−3 | 1.94 × 10−5 | 3.76 × 10−9 | 1.64 × 10−3 | 2.34 × 10−11 | CHSY1 |
| rs116643984 | 15 | 101791212 | 1.64 × 10−1 | 7.73 × 10−5 | 5.14 × 10−8 | 4.04 × 10−13 | 6.86 × 10−3 | 1.60 × 10−14 | CHSY1 |
| rs73937040 | 18 | 3258733 | 7.08 × 10−2 | 2.07 × 10−2 | 7.77 × 10−6 | 4.67 × 10−8 | 2.06 × 10−6 | 1.17 × 10−12 | MYL12A/MYL12B |
| rs146827176 | 20 | 35169916 | 6.48 × 10−1 | 3.10 × 10−6 | 1.01 × 10−3 | 2.13 × 10−9 | 5.08 × 10−3 | 3.82 × 10−11 | LOC101926987|MYL9 |
Abbreviations: CHR, chromosome; DBP, diastolic blood pressure; ICBP, International Consortium for Blood Pressure; MVP, Million Veteran Program; PP, pulse pressure; SBP, systolic blood pressure; SNP, single‐nucleotide polymorphism; UKB, UK Biobank.
a
The p values of pleiotropy test for BPpleio1 and BPpleio2 were consistent in general and we reported the lesser one here. The detailed summary statistics and corresponding p values were listed in Table S3.