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FOXP3-transcribed CCR4 expression regulates Treg infiltration in tumor site. Left: CCR4+ Tregs are infiltrated in the tumor microenvironment in response to tumor-secreted CCL22/CCL17 to promote tumor immune escape. Right: FOXP3 in the association of HAT1 binds to CCR4 promoter to epigenetically modify it for optimal transcription of CCR4 gene.
