Table 1.
Case–control analyses for CXCL12 polymorphisms (crude analyses)
| Polymorphism | Model | Genotype | Control (%) | Case (%) | OR (95% CI) | P |
|---|---|---|---|---|---|---|
| rs1801157 | Codominant | G/G | 293(65.4%) | 259(58.6%) | 1 | |
| G/A | 134(29.9%) | 167(37.8%) | 1.410 (1.063–1.869) | 0.017 | ||
| A/A | 21(4.7%) | 16(3.6%) | 0.862 (0.440–1.687) | 0.665 | ||
| Dominant | G/G | 293(65.4%) | 259(58.6%) | 1 | ||
| G/A-A/A | 155(34.6%) | 183(42.4%) | 1.336 (1.018–1.752) | 0.037 | ||
| Recessive | G/G-G/A | 427(95.3%) | 426(96.4%) | 1 | ||
| A/A | 21(4.7%) | 16(3.6%) | 0.764 (0.393–1.484) | 0.426 | ||
| Log-additive | – | – | – | 1.192 (0.947–1.501) | 0.135 | |
| rs2297630 | Codominant | G/G | 330(73.5%) | 325(73.7%) | 1 | |
| G/A | 108(24.1%) | 107(24.3%) | 1.01 (0.74–1.37) | 0.97 | ||
| A/A | 11(2.5%) | 9(2.0%) | 0.83 (0.34–2.03) | 0.68 | ||
| Dominant | G/G | 330(73.5%) | 325(73.7%) | 1 | ||
| G/A-A/A | 119(26.5%) | 116(26.3%) | 0.99 (0.73–1.33) | 0.95 | ||
| Recessive | G/G-G/A | 438(97.5%) | 432(98.0%) | 1 | ||
| A/A | 11(2.5%) | 9(2.0%) | 0.83 (0.34–2.02) | 0.68 | ||
| Log-additive | – | – | – | 0.98 (0.75–1.27) | 0.86 | |
| rs2839693 | Codominant | C/C | 316(70.4%) | 321(73.0%) | 1 | |
| C/T | 127(28.3%) | 110(25.0%) | 0.85 (0.63–1.15) | 0.30 | ||
| T/T | 6(1.3%) | 9(2.0%) | 1.48 (0.52–4.20) | 0.46 | ||
| Dominant | C/C | 316(70.4%) | 321(73%) | 1 | ||
| C/T-T/T | 133(29.6%) | 119(27%) | 0.88 (0.66–1.18) | 0.39 | ||
| Recessive | C/C–C/T | 443(98.7%) | 431(98.0%) | 1 | ||
| TT | 6(1.3%) | 9(2.0%) | 1.54 (0.54–4.37) | 0.42 | ||
| Log-additive | – | – | – | 0.93 (0.71–1.21) | 0.57 |
OR odds ratio, CI confidence interval