Table 3.

Timeline of dental extractions and manifestation of osteoradionecrosis (ORN)

Author	Primary tumor location	TN stage	ORN location	ORN onset after IMRT (months)	Patient had pre-IMRT extraction	Patient had post-IMRT extraction	Pre-IMRT extraction related to ORN	Post-IMRT extraction related to ORN
Ben-David et al. [19]	No ORN observed
Gomez et al. [20]	Floor of mouth	T2N1	Mandible	31	No	n.a.	No	n.a.
	Floor of mouth	T2N2b	Mandible	32	No	n.a.	No	n.a.
Maesschalck et al. [21]	Oropharynx	T1 (n = 0) T2 (n = 2) T3 (n = 1) T4 (n = 6)	Mandible	54	n.a.	Yes	No	Yes
	Oropharynx		Mandible	23	n.a.	No	No	No
	Oropharynx		Mandible	7	n.a.	Yes	No	Yes
	Oropharynx		Mandible	n.a.	n.a.	Yes	No	No
	Oropharynx		Mandible	32	Probably	No	n.a.	No
	Oropharynx		Mandible	8	n.a.	Yes	No	Yes
	Oropharynx		Mandible	28	No	No	No	No
	Oropharynx		Mandible	31	n.a.	Yes	No	Yes
	Oropharynx		Mandible	2	Yes	No	Yes	No
Muraki et al. [22]	Hypopharynx	T3N0	Mandible	3	No	No	No	No
	Oropharynx	T4aN2b	Mandible	11	No	No	No	No
	Oropharynx	T3N0	n.a.	18	Yes	Yes	No	No
Schuurhuis et al. [23]	Oral Cavity or Oropharynx	n.a.	Mandible	3	Yes	n.a.	Yes	No
		n.a.	Mandible	7	n.a.	Yes	No	Yes
		n.a.	Mandible	2	n.a.	n.a.	No	No
		n.a.	Transplant	2	n.a.	n.a.	No	No
See Toh et al. [24]	Nasopharynx	T1 (n = 1) T2 (n = 0) T3 (n = 2) T4 (n = 3)	Maxilla	10	Yes	No	5/6 Yes a	No
	Nasopharynx		Mandible	6	Yes	No		No
	Nasopharynx		Mandible	3	Yes	No		No
	Nasopharynx		Mandible	1	Yes	No		No
	Nasopharynx		Mandible	24	Yes	No		No
	Nasopharynx		Mandible	4	Yes	No		No
Willaert et al. [25]	Oropharynx (n = 3) Hypopharynx (n = 1)	n.a.	Mandible	51.6	n.a.	Yes	No	Yes
		n.a.	Mandible	54.3	Yes	n.a.	Yes	No
		n.a.	Mandible	67.7	n.a.	n.a.	No	No
		n.a.	Mandible	6.7	n.a.	Yes	No	Yes

IMRT intensity-modulated radiotherapy, n.a. not available

^a In five of six cases, patients had teeth removed prior to irradiation at the areas that subsequently developed ORN. One case occurred spontaneously