Table 2.
Factors associated with the risk of complications after prostate cancer surgery according to the Clavien-Dindo System (CDS) in 1062 cases (multivariate models)
| Exposure variable | Radical prostatectomy | Extended pelvic lymph node dissection | Estimated blood lost above the third quartile | |||
|---|---|---|---|---|---|---|
| Level of exposure | RARP | ORP | No | Yes | No | Yes |
| CDS > 0 vs. CDS < 1 | ||||||
| CDS < 1; n (%) | 667 (74.9) | 85 (49.7) | 322 (78.3) | 430 (66.1) | 654 (73.1) | 98 (58.7) |
| CDS > 0; n (%) | 224 (25.1) | 86 (50.3) | 89 (21.7) | 221 (33.9) | 241 (26.9) | 69 (41.3) |
| OR (95%CI) | 1 | 2,369 (1647–3.407) (*) | 1 | 1,528 (1133–2060) (**) | 1 | 1462 (1013–2108) (^) |
| p value | < 0.0001 | 0.005 | 0.042 | |||
| CDS > 1 vs. CDS < 2 | ||||||
| CDS < 2; n (%) | 804 (90.2) | 111 (64.9) | 378 (92) | 537 (82.5) | 790 (88.3) | 125 (74.9) |
| CDS ≥ 2; n (%) | 87 (9.8) | 60 (35.1) | 33 (8) | 114 (17.5) | 105 (11.7) | 42 (25.1) |
| OR (95%CI) | 1 | 3710 (2431–5662) (*) | 1 | 1694 (1096–2617) (**) | 1 | 1633 (1046–2548) (^) |
| p value | < 0.0001 | 0.002 | 0.018 | 0.031 | ||
| CDS > 2 vs CDS < 3 | ||||||
| CDS < 3; n (%) | 866 (97.2) | 138 (80.7) | 401 (97.6) | 603 (92.6) | 854 (95.4) | 150 (89.8) |
| CDS ≥ 3; n (%) | 25 (2.8) | 33 (19.3) | 10 (2.4) | 48 (7.4) | 41 (4.6) | 17 (10.2) |
| OR (95%CI) | 1 | 8283 (4780–14,355) | 1 | 3090 (1543–6191) (***) | 1 | 2239 (1233–4064) (^^) |
| p value | < 0.0001 | 0.001 | 0.008 | |||
OR odds ratio; CI confidence interval; RARP robot-assisted radical prostatectomy; ORP open radical prostatectomy; (*), OR adjusted for extended pelvic lymph node dissection and blood lost above the third quartile; (**), OR adjusted for ORP and blood lost above the third quartile; (***), OR adjusted for blood lost above the third quartile; (^), adjusted for ORP and ePLND; (^^), adjusted for ePLND