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. 2021 Jul 16;83(2):117–123. doi: 10.1007/s00056-021-00326-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Experimental anterior orthodontic tooth movement (OTM) of the first upper left molar (M1) by insertion of an elastic band (774-200-01, Dentaurum, Ispringen, Germany) between the first (M1) and second (M2) upper left molar according to the Waldo/Rothblatt method. b Axial T1-MRI section at the root level of the rat molars before i.v. injection of the VEGFR‑2 molecular marker. c Axial T1-MRI plane at the root level of the rat molars after i.v. injection of the VEGFR‑2 molecular marker. d Area under the curve (AUC) mapping of dynamic contrast-enhanced MRI (DCE-MRI). VEGFR vascular endothelial growth factor, OTM left jaw side with orthodontic tooth movement; control untreated right jaw side

a Experimentelle kieferorthopädische Zahnbewegung (OTM) des ersten oberen linken Molaren (M1) durch Insertion eines elastischen Bandes (774-200-01, Dentaurum, Ispringen, Deutschland) zwischen dem ersten (M1) und zweiten (M2) oberen linken Molaren nach der Waldo/Rothblatt-Methode. b Axialer T1-MRT-Schnitt auf Wurzelniveau der Molaren der Ratte vor i.v.-Injektion des molekularen Markers VEGFR‑2. c Axiale T1-MRT-Ebene auf Wurzelniveau der Molaren der Ratte nach i.v.-Injektion des molekularen Markers VEGFR‑2. d AUC(Fläche unter der Kurve)-Kartierung der DCE-MRI. VEGFR „vascular endothelial growth factor“, OTM linke Kieferseite mit kieferorthopädischer Zahnbewegung; Kontrolle unbehandelte rechte Kieferseite