Table 4.
Odds ratios assessing the association of predictors with upgrade of clinically significant prostate cancer from conditional logistic regression models at the sextant level
| Predictors | Category | Rate of upgrade | Odds ratio | p-value |
|---|---|---|---|---|
| Univariate model | ||||
| MRI target | Absent | 100/3776 (2.65%) | 2.58 (95% CI 1.87–3.63) | < 0.001 |
| Present | 91/1732 (5.25%) | |||
| US target | Absent | 158/4762 (3.32%) | 1.83 (95% CI 1.14–2.93) | 0.01 |
| Present | 33/746 (4.42%) | |||
| Ipsilateral target | Absent | 23/1527 (1.51%) | 3.89 (95% CI 2.36–6.42) | < 0.001 |
| Present | 168/3981 (4.22%) | |||
| Multivariate model 1 | ||||
| MRI target (in US- sextants) | Absent | 90/3534 (2.55%) | 2.87 (95% CI 1.94–4.25) | < 0.001 |
| Present | 68/1228 (5.54%) | |||
| MRI target (in US + sextants) | Absent | 10/242 (4.13%) | 1.01 (95% CI 0.39–2.61) | 0.98 |
| Present | 23/504 (4.56%) | |||
| US target (in MRI- sextants) | Absent | 90/3534 (2.55%) | 2.45 (95% CI 1.08–5.58) | 0.03 |
| Present | 10/242 (4.13%) | |||
| US target (in MRI + sextants) | Absent | 68/1228 (5.54%) | 0.86 (95% CI 0.46–1.62) | 0.65 |
| Present | 23/504 (4.56%) | |||
| Multivariate model 2 | ||||
| MRI target | – | – | 2.14 (95% CI 1.32–3.45) | 0.002 |
| MRI target:PSA density | – | – | 1.47 (95% CI 0.74–2.94) | 0.27 |
| Multivariate model 3 | ||||
| US target | – | – | 1.77 (95% CI 0.87–3.59) | 0.12 |
| US target:PSA density | – | – | 1.06 (95% CI 0.41–2.75) | 0.90 |
| Multivariate model 4 | ||||
| Ipsilateral lesion | – | – | 2.52 (95% CI 1.32–4.82) | 0.005 |
| Ipsilateral lesion:PSA density | – | – | 2.63 (95% CI 0.94–7.38) | 0.07 |