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. 2022 Feb 9;10:812110. doi: 10.3389/fcell.2022.812110

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Copyright © 2022 Valdés-López, Fernandez and Urcuqui-Inchima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR1/2-MyD88, but not TLR3-TRIF signaling, activates NF-κB-complex and induces EBI3 expression in murine BMDM. We reanalyzed the public MicroArray GSE89962 (GEO) (Lin et al., 2017), obtained from BMDM of C57BL/6 mice stimulated with 10 ng/ml Pam3CSK4 and/or 10 μg/ml Poly (I:C), for 8 h. Differentially expressed (Log2 FC) TLR signaling components (A), NF-κB-complex (B), and NF-κB-target genes (C). DEGs were defined as genes with an FDR< 0.05 and |Log2 Fold Change (TLR-treated BMDM/unstimulated BMDM) |> 0.6. Significant results are defined as p < 0.05 (*). n = 3.