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. 2022 Feb 9;10:812110. doi: 10.3389/fcell.2022.812110

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Copyright © 2022 Valdés-López, Fernandez and Urcuqui-Inchima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR4 activation triggers the expression of IL27, which induces STAT1-dependent pro-inflammatory and antiviral responses in human MDMs. We reanalyzed a publicly available RNA-seq dataset [GSE84188 (GEO) (Olejnik et al., 2017)], obtained from human MDMs stimulated with 100 ng/ml of LPS, for 6, 24 or 48 h. Differentially expressed IRFs (A), inductors of antiviral response (B), IL27 signaling pathway components (C), AVPs (D), STAT1-dependent cytokines (E), and STAT1-dependent CC- and CXC-chemokines (F). Data are presented as the mean ± SEM. Kruskal–Wallis test with Dunn’s post-test was performed. Significant results between unstimulated and LPS-stimulated MDMs are defined as p < 0.05 (*), p < 0.01 (**) and p < 0.002 (***). Significant results between treatment-times comparisons are defined as p < 0.05 (#), p < 0.01 (##) and p < 0.002 (###).