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. 2022 Feb 22;12:3027. doi: 10.1038/s41598-022-06809-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of miRNA profile in EVs of PSC-derived circulating EVs. (A) Volcano plots illustrating significantly differentially abundant EV-miRNAs in PSC patients vs. healthy controls. The − log10 (adjusted p-value) is plotted against the log2 fold-change. (B) Unsupervised hierarchical clustering analysis of the top 11 differentially expressed circulating EV-miRNAs identified by miRNA-sequencing in PSC patients vs. healthy controls. An adjusted p-value of 0.05 was used to generate the heatmaps. The closer the color is to bright blue, the lower the expression while the closer the color is to bright red, the higher the expression. (C) KEGG pathway enrichment analysis of top 10 differentially expressed EV-miRNAs. KEGG is developed by Kanehisa Laboratories and a copyright request was approved for the use of this tool in this manuscript.