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. 2022 Feb 22;12:2996. doi: 10.1038/s41598-022-06542-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cardiac function and LV strain were analysed by ultrahigh magnetic field 7-T MRI. (A) LVEF, LVEDV, LVESV, LVSV, and LVM were measured in the C, N, and NP groups. (B) and (C) myocardial strain values in three directions (longitudinal, circumferential, and radial) were analysed using cvi42 software. The yellow arrowheads indicate areas of decreased LV strain. The results are presented as the mean ± SD, and p values were calculated using one-way ANOVA with Tukey’s post hoc test. *P < 0.05, **P < 0.01, C vs. N group or N vs. NP group. The number of mice in each group: C, n = 5; N, n = 5; NP, n = 5. LVEF, left ventricle ejection fraction; LVEDV, left ventricular end-diastolic volume; LVESV, left ventricular end-systolic volume; LVSV, left ventricular stroke volume; LVM, left ventricular mass; LS, longitudinal strain; CS, circumferential strain; RS, radial strain.