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. 2022 Feb 22;12:2996. doi: 10.1038/s41598-022-06542-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cardiac phenotypes and histological images. (A) Body weight, heart/body weight, and lung/body weight were measured. (B) Cardiac WGA staining was performed, and the mean area per cardiomyocyte was measured. (C) Cardiac cholesterol contents were measured. (D) Cardiac H.E., F4/80, and MT staining in each group. The red arrows indicate the infiltration sites of F4/80-positive macrophages. (E) Flow cytometry analysis of cells isolated from collagenase-treated hearts. Myocardial leukocyte fraction was measured. The results are presented as the mean ± SD, and p values were calculated using one-way ANOVA with Tukey’s post hoc test. *P < 0.05, **P < 0.01 and ***P < 0.001; C vs. N group or N vs. NP group. The number of mice in each group: C, n = 10 (A), n = 5 (B-E); N, n = 10 (A), n = 5 (B-E); NP, n = 10 (A), n = 5 (B-E). WGA, wheat germ agglutinin; EC, esterified cholesterol; H.E., haematoxylin–eosin; M.T., Masson's trichrome.