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. 2022 Feb 22;12:2996. doi: 10.1038/s41598-022-06542-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of pemafibrate after the development of steatohepatitis and cardiomyopathy. (A) Chow diet, chow diet + 0.1 mg/kg pemafibrate, NASH diet, or NASH diet + 0.1 mg/kg pemafibrate diet was fed to C57Bl6 male mice for 4 weeks after feeding the NASH diet for 8 weeks (N–C, N-CP, N–N, and N-NP groups, respectively). Cardiac MRI was performed before and after the additional diet in the N–N and N-NP groups. (B) Liver H. E, O.R.O., F4/80, and S.R. staining in N–C and N-CP groups. (C) Percentages of examined areas positive for F4/80 and Sirius Red. (D) LVEF, LVSV, and LVM in N–N and N-NP groups. Pre- and post-LVEF, the ratios of post/pre LVSV and post/pre LVM are shown. Scale bar: 100 µm. The results are presented as the mean ± SD, and p values were calculated using Student’s t test. *P < 0.05, N–C vs. N-CP or N–N vs. N-NP group. The number of mice in each group: N–C, n = 6; N-CP, n = 6; N–N, n = 6; N-NP, n = 6. H.E., haematoxylin–eosin; O.R.O., Oil Red O; S.R., Sirius Red; LVEF, left ventricle ejection fraction; LVSV, left ventricular stroke volume; LVM, left ventricular mass.