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. 2022 Feb 22;8:77. doi: 10.1038/s41420-022-00850-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A RT-qPCR validation of miR-15a mimic transfection efficiency in HGF-treated BMSCs. B RT-qPCR validation of oe-SMURF1 overexpression efficiency in HGF-treated BMSCs. C Changes in the levels of hepatocyte-related genes after overexpression of miR-15a for 14 days determined by RT-qPCR. D Changes in the levels of hepatocyte-related genes after overexpression of SMURF1 for 14 days measured by RT-qPCR, E RT-qPCR to assess the ALB content in the culture supernatant of BMSCs after overexpressing miR-15a for 14 days. F RT-qPCR to evaluate the secretion of ALB of BMSCs after overexpressing SMURF1 for 14 days; G Glycogen content in BMSCs after overexpressing miR-15a or SMURF1 for 14 days detected by PAS staining. *p < 0.05 vs. BMSCs transfected with oe-NC or NC mimic. The cell experiments were repeated three times.