Table 1.
Sociodemographic and clinical characteristics of patients receiving limb salvage vs. amputation in pediatric osteosarcoma patients.
| Unmatched | Matched | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Overall N = 1,058 | Limb salvage N = 822 | Amputation N = 236 | p-value | SMD | Overall N = 472 | Limb salvage N = 236 | Amputation N = 236 | p-value | SMD | |
| Age [mean (SD)] | 12.751 (3.377) | 12.809 (3.264) | 12.551 (3.745) | 0.3009 | 0.073 | 12.449 (3.529) | 12.347 (3.304) | 12.551 (3.745) | 0.5319 | 0.058 |
| Sex | 0.042 | 0.157 | 0.638 | 0.052 | ||||||
| Male | 591 (55.9%) | 445 (54.1%) | 146 (61.9%) | 286 (60.6%) | 140 (59.3%) | 146 (61.9%) | ||||
| Female | 467 (44.1%) | 377 (45.9%) | 90 (38.1%) | 186 (39.4%) | 96 (40.7%) | 90 (38.1%) | ||||
| Year of diagnosis | 0.289 | 0.084 | 0.051 | 0.189 | ||||||
| 2004-2011 | 517 (48.9%) | 394 (47.9%) | 123 (52.1%) | 268 (56.8%) | 145 (61.4%) | 123 (52.1%) | ||||
| 2012-2018 | 541 (51.1%) | 428 (52.1%) | 113 (47.9%) | 204 (43.2%) | 91 (38.6%) | 113 (47.9%) | ||||
| Race | 0.054 | 0.181 | 0.205 | 0.165 | ||||||
| white | 788 (74.5%) | 610 (74.2%) | 178 (75.4%) | 347 (73.5%) | 169 (71.6%) | 178 (75.4%) | ||||
| black | 154 (14.6%) | 129 (15.7%) | 25 (10.6%) | 63 (13.3%) | 38 (16.1%) | 25 (10.6%) | ||||
| other | 116 (11.0%) | 83 (10.1%) | 33 (14.0%) | 62 (13.1%) | 29 (12.3%) | 33 (14.0%) | ||||
| Grade | 0.847 | 0.092 | 0.871 | 0.104 | ||||||
| I | 17 (1.61%) | 14 (1.70%) | 3 (1.27%) | 7 (1.48%) | 4 (1.69%) | 3 (1.27%) | ||||
| II | 28 (2.65%) | 22 (2.68%) | 6 (2.54%) | 13 (2.75%) | 7 (2.97%) | 6 (2.54%) | ||||
| III | 247 (23.3%) | 198 (24.1%) | 49 (20.8%) | 106 (22.5%) | 57 (24.2%) | 49 (20.8%) | ||||
| IV | 497 (47.0%) | 382 (46.5%) | 115 (48.7%) | 220 (46.6%) | 105 (44.5%) | 115 (48.7%) | ||||
| Unknown | 269 (25.4%) | 206 (25.1%) | 63 (26.7%) | 126 (26.7%) | 63 (26.7%) | 63 (26.7%) | ||||
| Laterality | 0.996 | 0.006 | 1.000 | 0.008 | ||||||
| Left | 558 (52.7%) | 433 (52.7%) | 125 (53.0%) | 249 (52.8%) | 124 (52.5%) | 125 (53.0%) | ||||
| Right | 500 (47.3%) | 389 (47.3%) | 111 (47.0%) | 223 (47.2%) | 112 (47.5%) | 111 (47.0%) | ||||
| T | 0.034 | 0.195 | 0.511 | 0.107 | ||||||
| T1 | 363 (34.3%) | 298 (36.3%) | 65 (27.5%) | 140 (29.7%) | 75 (31.8%) | 65 (27.5%) | ||||
| T2 | 658 (62.2%) | 498 (60.6%) | 160 (67.8%) | 313 (66.3%) | 153 (64.8%) | 160 (67.8%) | ||||
| T3 | 37 (3.50%) | 26 (3.16%) | 11 (4.66%) | 19 (4.03%) | 8 (3.39%) | 11 (4.66%) | ||||
| N | 0.438 | 0.049 | 1.000 | 0.028 | ||||||
| N0 | 1037 (98.0%) | 807 (98.2%) | 230 (97.5%) | 461 (97.7%) | 231 (97.9%) | 230 (97.5%) | ||||
| N1 | 21 (1.98%) | 15 (1.82%) | 6 (2.54%) | 11 (2.33%) | 5 (2.12%) | 6 (2.54%) | ||||
| M | <0.001 | 0.326 | 0.681 | 0.047 | ||||||
| M0 | 863 (81.6%) | 695 (84.5%) | 168 (71.2%) | 341 (72.2%) | 173 (73.3%) | 168 (71.2%) | ||||
| M1 | 195 (18.4%) | 127 (15.5%) | 68 (28.8%) | 131 (27.8%) | 63 (26.7%) | 68 (28.8%) | ||||
| Radiation | 0.121 | - | 0.5738 | - | ||||||
| No/Unknown | 1036 (97.9%) | 808 (98.3%) | 228 (96.6%) | 459 (97.25) | 231 (97.88) | 228 (96.61) | ||||
| Yes | 22 (2.08%) | 14 (1.70%) | 8 (3.39%) | 13 (2.75) | 5 (2.12) | 8 (3.39) | ||||
| Chemotherapy | 0.238 | - | 0.0925 | - | ||||||
| No/Unknown | 38 (3.59%) | 33 (4.01%) | 5 (2.12%) | 18 (3.81) | 13 (5.51) | 5 (2.12) | ||||
| Yes | 1020 (96.4%) | 789 (96.0%) | 231 (97.9%) | 454 (96.19) | 223 (94.49) | 231 (97.88) | ||||
| Tumor.size [mean (SD)] | 107.319 (60.855) | 105.439 (62.501) | 113.869 (54.354) | 0.0607 | 0.144 | 111.750 (61.667) | 109.631 (68.252) | 113.869 (54.354) | 0.456 | 0.069 |