Table 3.

Propensity score-adjusted multivariate Cox regression models predict cancer-specific mortality and other causes mortality in pediatric osteosarcoma patients.

	Cancer-specific mortality			Other cause mortality
	HR	(5–95% CI)	p-value	HR	(5–95% CI)	p-value
Age	1.028	0.979–1.08	0.272	1.004	0.864–1.167	0.957
Sex				1.132	0.366–3.503	0.83
Male	Reference			Reference
Female	0.932	0.661–1.312	0.685	1.132	0.366–3.503	0.83
Year of diagnosis
2004–2011	Reference			Reference
2012–2018	1.071	0.746–1.537	0.709	0.411	0.043–3.917	0.44
Race
white	Reference			Reference
black	0.843	0.506–1.403	0.511	0.899	0.184–4.384	0.895
other	1.3	0.807–2.092	0.28	0.645	0.079–5.297	0.683
Grade
I	Reference			Reference
II	0.843	0.506–1.403	0.511	0.882	0-1.82E+143	0.999
III	1.3	0.807–2.092	0.28	2071.991	0-7.63E+120	0.956
IV	0.843	0.506–1.403	0.511	3033.215	0-1.11E+121	0.954
Unknown	1.3	0.807–2.092	0.28	3850.809	0-1.42E+121	0.952
Laterality
Left	Reference			Reference
Right	0.804	0.571–1.132	0.212	0.683	0.221-2.112	0.508
T
T1	Reference			Reference
T2	0.942	0.589–1.506	0.802	0.446	0.103-1.921	0.278
T3	1.291	0.581–2.868	0.53	0	0-3.58E+78	0.924
N
N0	Reference			Reference
N1	1.422	0.601–3.364	0.423	0	0-3.53E+114	0.954
M
M0	Reference			Reference
M1	3.347	2.34–4.786	<0.001	2.689	0.602–12.021	0.195
Surgery
Limb salvage	Reference			Reference
Amputation	1.525	1.097–2.121	0.012	3.171	0.972–10.342	0.056
Tumor size	1.003	1–1.005	0.037	1.001	0.99–1.012	0.839