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. 2022 Feb 22;12:2987. doi: 10.1038/s41598-022-06846-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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aSyn-Tau interaction in mouse substantia nigra pars compacta (SNpc). BiFC interaction in mouse SNpc. 10–12-week-old mice were injected in SNpc with AAV6 carrying different BiFC constructs. After 15 weeks, Venus fluorescence was evaluated. The expression of aSyn fused to full-length Venus provided the maximum level of fluorescence expected. The interaction of aSyn and Tau was reflected by Venus complementation in VN-aSyn + Tau WT-VC and VN-Tau WT + aSyn-VC injected animals. As expected, the expression of the Venus halves not linked to proteins did not produce any fluorescence in the injected area. Boxed area on Bright Field (B/F) images is magnified to the right. Scale bar: 25 µm.