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. 2022 Feb 22;12:2987. doi: 10.1038/s41598-022-06846-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular characterization of aSyn-Tau interaction in rat SNpc. aSyn-Tau interaction in rat SNpc. Eight weeks after co-injection of VN-aSyn and Tau WT-VC in rat SNpc immunohistochemistry was performed. (A) Immunohistochemistry for phosphorylated epitopes of aSyn (pS129) and Tau (AT8) suggests that aSyn and Tau can be phosphorylated while they are interacting with each other. Scale bar: 50 µm (B) Distribution of aSyn and Tau after injection of VN-aSyn and Tau WT-VC in rat SNpc. aSyn distribution shows a clear transport of aSyn from the injected area to the striatum. In contrast, the expression of human Tau seems to be confined to the SNpc.