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. 2022 Feb 9;13:851004. doi: 10.3389/fimmu.2022.851004

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Copyright © 2022 Guo, Xie and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of lncRNA function and tumor immune microenvironment. (A) LncRNA regulate their targets via various mechanisms, including both the transcriptional and post transcriptional levels. (1) MicroRNA sponge; (2) interaction with protein; (3) interaction with mRNA; (4) peptide formation; (5) lncRNA in MVBs; (6) Chromatin modification; (7) DNA interaction. (B) Components of the tumor immune microenvironment. The tumor immune microenvironment is a complex ecosystem, consist of cancer cells, immune cells, and vascular network, etc. Induced by the cytokines, chemokines, and growth factors, tumor-infiltrating immune cells of both the myeloid and lymphoid lineages are recruited and activated. Created with BioRender.com.