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. 2022 Feb 9;13:851004. doi: 10.3389/fimmu.2022.851004

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Copyright © 2022 Guo, Xie and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA and adaptive immune cells in TIME. In the TIME, lncRNA can regulate adaptive immune cells to interact with tumor cells. T cells and B cells are the main adaptive immune cells. T cells play different immunomodulatory effects depending the various subgroups. Cytotoxic T cells have the tumor killing abilities and Treg cells play an immunosuppressive role. LncRNA has been revealed to participate in adaptive immune cells’ development, activation, differentiation, function, and cancer immunology. Created with BioRender.com.