Table 2.
PICO questions and recommendations in travellers, health care workers, and asymptomatic individuals at risk for exposure
| B | PICO question | Recommendation | Strength of recommendationa | Overall certainty of evidenceb | References |
|---|---|---|---|---|---|
| 1 | In travellers from areas with low prevalence, should surveys for contact history with known or suspected exposures to infected people followed by NAAT be used compared with universal NAAT to diagnose COVID-19? | In returning travellers from areas with low prevalence of COVID-19, we suggest the use of universal NAAT versus survey for contact history with known or suspected exposures in addition to NAAT for diagnosis of COVID-19. | Weak against | Very low | [[119], [120], [121]] |
| 2 | In travellers from areas with high prevalence, should surveys for contact history with known or suspected exposures to infected people followed by NAAT be used compared with universal NAAT to diagnose COVID-19? | In returning travellers from areas with high prevalence of COVID-19, we suggest the use of universal NAAT versus survey for contact history with known or suspected exposures in addition to NAAT for diagnosis of COVID-19. | Weak against | Very low | [121,122] |
| 3 | In health care workers, should surveys for contact history with known or suspected exposures to infected people followed by NAAT be used compared with universal NAAT to diagnose COVID-19? | In health care workers, we recommend the use of universal NAAT versus survey for contact history with known or suspected exposures in addition to NAAT for diagnosis of COVID-19. | Strong against | Very low | [119,121] |
| 4 | In asymptomatic populations at risk for exposure, should surveys for contact history with known or suspected exposures within <7 days to infected people followed by NAAT be used compared with universal NAAT to diagnose COVID-19? | In asymptomatic populations at risk for exposure, we suggest the use of universal NAAT versus survey for contact history with known or suspected exposures within <7 days in addition to NAAT for diagnosis of COVID-19. | Weak against | Very low | [[119], [120], [121], [122]] |
| 5 | In asymptomatic populations at risk for exposure, should surveys for contact history with known or suspected exposures >7 days to infected people followed by NAAT be used compared with universal NAAT to diagnose COVID-19? | In asymptomatic populations at risk for exposure, we suggest the use of universal NAAT versus survey for contact history with known or suspected exposures >7 days in addition to NAAT for diagnosis of COVID-19. | Weak against | Very low | [[119], [120], [121], [122]] |
NAAT, rapid nucleic acid amplification test; PICO, patient/population, intervention.
a
Strength of recommendation (strong against, weak against, in research only, weak for, strong for).
b
Overall certainty of the evidence (high, moderate, low, very low).