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. 2022 Feb 22;13:997. doi: 10.1038/s41467-022-28326-4

Fig. 2. Mean R1 and mean MD of white matter bundles develop linearly from birth to 6 months of age.

Fig. 2

a Mean R1 of each bundle as a function of age in days. Each point is a participant; markers indicate hemisphere; lines indicate LMM prediction; lines for both hemispheres fall on top of each other; gray shaded regions indicate 95% confidence intervals. b Mean R1 measured in newborns (N = 9) for 24 white matter bundles. c Rate of mean R1 development (slopes from LMMs) during the first 6 months of life for each white matter bundle; Bundles are sorted by R1 at birth. d Mean MD measured in newborns (N = 9) for 24 white matter bundles. e Mean MD decreases linearly from 0 to 6 months, which can be modeled by LMMs (Supplementary Fig. 5). Here we show the rate of mean MD development (LMM slopes) during the first 6 months of life for each white matter bundle. Note that slopes are negative; Bundles are sorted by MD at birth. b–e Color: bundle; Darker shades: LH. Error bars: Standard error. Source data are provided as a Source Data file. CS cortico-spinal tract, ATR anterior thalamic radiation, FcMa forceps major, FcMi forceps minor, VOF vertical occipital fasciculus, pAF posterior arcuate fasciculus, AF arcuate fasciculus, UCI uncinate fasciculus, SLF superior longitudinal fasciculus, CC cingulum cingulate, ILF inferior longitudinal fasciculus, MLF middle longitudinal fasciculus, IFOF inferior frontal occipital fasciculus, RH right hemisphere, LH left hemisphere.