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. 2022 Feb 22;12:3274. doi: 10.1038/s41598-022-07002-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results from analyzing 7137 viral genomes sequenced by laboratories in Washington state and deposited to GISAID. (A) Results from counting mutational numbers per nucleotide throughout the viral genome. Upper arrow indicates observed counts greater than 300. The viral genome is annotated with gene designations immediately below. (B) Computed q-values and maximum values of variant proportions in November 2020, December 2020, and January 2021, obtained from fitting generalized linear models to all individual SNVs. SNVs exceeding established threshold q-value and maximum proportions are highlighted in red (upper right corner). (C) Eight selected SNVs with significant and substantial temporalities are mapped using their locally averaged variant proportions over time from fitted generalized linear models (color key upper left).