Table 3.
Absorbed cumulative radiation dose estimates of [131I]SGMIB-2Rs15d and iso-[131I]SGMIB-VHH_1028 to kidneys and tumors for a hypothetical dose of 37 MBq.
| Animal model | sdAb | Prosthetic agent | Cumulative activity (µCi*h/g) | Radiation dose (cGy) | ||
|---|---|---|---|---|---|---|
| Kidney | Tumor | Kidney | Tumor | |||
| SKOV-3 | VHH_1028 | iso-[131I]SGMIB | 445 | 2326 | 192 | 1003 |
| 2Rs15d | [131I]SGMIB | 849 | 1541 | 366 | 665 | |
| BT474 | VHH_1028 | iso-[131I]SGMIB | 1000 | 8805 | 431 | 3798 |
| 2Rs15d | [131I]SGMIB | 2127 | 2965 | 917 | 1279 | |
Estimates were based on biodistribution data in Tables 1 and 2. Cumulative radioactivity were calculated using the trapezoid integration method by calculating area under the activity/g tissue curves, extrapolating to when negligible activity remained. They were converted to absorbed cumulative dose by multiplying the equilibrium absorbed dose constant for 131I, 0.4313 g*cGy/(µCi*h).