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. 2022 Feb 23;7:52. doi: 10.1038/s41392-022-00872-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Targeting IL6/JAK2/STAT3 signaling for suppression of A549-F3 metastasis in vivo. a Brain metastases were determined by bioluminescence imaging. b Histogram showed incidence of brain metastasis in the different groups. c Photon flux detected from brain-metastatic focus in the different groups. d Brain metastases were determined by bioluminescence imaging. e Histogram showed incidence of brain metastasis in the different groups. f Photon flux detected from brain-metastatic focus in the different groups. g Kaplan–Meier estimates of the cumulative probability of brain metastasis among. NSCLC patients according to the level of IL6 in serum. h Kaplan–Meier survival curves of NSCLC patients with IL6 high expression and IL6 low expression. i Proposed model for IL6/JAK2/STAT3 activation in M2-microglia to promote colonization of brain-metastatic cells. Data are mean ± SD. *P < 0.05; **P < 0.01