. 2022 Feb 22;12:2975. doi: 10.1038/s41598-022-06730-6

Table 1.

Quantitative results for IVO (top) and ProstateX (bottom) test data evaluated with different Gleason Grade Group (GGG) significance criteria (e.g. lesions with GGG $\geq$ 1, 2, or 3 are considered positive), at lesion- and patient-level ( $N_{positives} / N_{total}$ ), and at two thresholds (t): maximum sensitivity and balanced. For IVO data, results are compared with radiologist-assigned pre-biopsy PI-RADS scores for all IVO patients with no missing sequences and with PI-RADS information available (N=106 patients, 111 lesions). AUC: Area under the ROC curve.

(Dataset) & Significance criterion	Level	AUC	Max. sensitivity			Balanced			PI-RADS $\geq$ 4		PI-RADS=5
(Dataset) & Significance criterion	Level	AUC	t	Sens.	Spec.	t	Sens.	Spec.	Sens.	Spec.	Sens.	Spec.
IVO GGG $\geq$ 1	Lesion ( $13 / 33$ )	0.892	0.027	1.000	0.350	0.105	0.923	0.700	0.741	0.604	0.328	0.962
IVO GGG $\geq$ 1	Patient (15/30)	0.920	0.253	1.000	0.667	0.301	0.867	0.800	0.710	0.649	0.290	0.973
IVO GGG $\geq$ 2	Lesion (8/33)	0.945	0.173	1.000	0.800	0.301	0.875	0.920	0.882	0.558	0.441	0.922
IVO GGG $\geq$ 2	Patient (9/30)	0.910	0.219	1.000	0.762	0.262	0.889	0.810	0.850	0.576	0.400	0.924
IVO GGG $\geq$ 3	Lesion (3/33)	0.856	0.301	1.000	0.800	0.315	0.667	0.867	0.727	0.440	0.455	0.840
IVO GGG $\geq$ 3	Patient (3/30)	0.840	0.301	1.000	0.778	0.315	0.667	0.852	0.727	0.432	0.455	0.832
ProstateX GGG $\geq$ 1	Lesion (17/69)	0.898	0.028	0.941	0.788	0.053	0.824	0.865	–	–	–	–
ProstateX GGG $\geq$ 1	Patient (16/45)	0.866	0.108	1.000	0.138	0.104	0.938	0.655	–	–	–	–
ProstateX GGG $\geq$ 2	Lesion (13/69)	0.959	0.028	1.000	0.786	0.108	0.923	0.911	–	–	–	–
ProstateX GGG $\geq$ 2	Patient (13/45)	0.865	0.028	1.000	0.375	0.108	0.923	0.688	–	–	–	–
ProstateX GGG $\geq$ 3	Lesion (7/69)	0.751	0.195	0.714	0.887	0.195	0.714	0.887	–	–	–	–
ProstateX GGG $\geq$ 3	Patient (7/45)	0.767	0.016	1.000	0.395	0.026	0.857	0.500	–	–	–	–