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. 2022 Feb 22;13:1003. doi: 10.1038/s41467-022-28662-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — At baseline and at the end of the study, samples were collected from 19 participants (eTRF, n = 5; mTRF, n = 8; and control, n = 6). Plasma adipokine concentrations (resistin, leptin, and ghrelin) were measured at four time points. Two-way ANOVA analysis showed that eTRF (a, d, g) caused significant changes in the resistin concentration at 12:00 (p = 0.048) and 17:00 (p = 0.03) (a), and in the ghrelin concentration at 23:00 (p = 0.037) (g), but mTRF (b, e, h), or control groups (c, f, i) had no significant effects on the rhythm of adipokines. The values at each time point are displayed as the percentage of the mean value across all the time points and are displayed as means ± SEMs. Two-way repeated-measures ANOVA with time of day and feeding regimens as the two independent variables. ξp < 0.05 between baseline and follow-up at that time point. BL baseline, FU follow up.