Table 4.

The results of meta-regression analysis of SUVmax and ADC to differentiate benign and malignant ovarian or adnexal tumors.

Parameter	Category	No. of studies	Sensitivity	p-value	Specificity	p-value
SUVmax
Design	Prospective	3	0.88 [0.78–0.98]	0.19	0.92 [0.82–1.00]	0.67
	Retrospective	3	0.92 [0.84–1.00]		0.89 [0.82–0.96]
Mean age	≥56	3	0.92 [0.88–0.96]	0.07	0.92 [0.84–0.98]	0.96
	<56	3	0.92 [0.88–0.96]		0.91 [0.84–0.99]
Sample	>50	4	0.88 [0.82–0.95]	0.15	0.93 [0.81–0.97]	0.03
	≤50	3	0.88 [0.78–0.98]		0.85 [0.78–0.99]
Vendor	Just GE	3	0.94 [0.90–0.98]	0.33	0.85 [0.76–0.94]	0.10
	With Siemens	3	0.82 [0.76–0.89]		0.85 [0.76–0.94]
Cutoff value	≥3.0	4	0.91 [0.86–0.95]	0.01	0.90 [0.82–0.99]	0.51
	<3.0	3	0.84 [0.78–0.90]		0.87 [0.78–0.97]
Time between FDG administration and scanning	≥60 min	3	0.94 [0.88–0.99]	0.72	0.89 [0.80–0.99]	0.43
	<60 min	4	0.85 [0.78–0.91]		0.88 [0.78–0.97]
FDG dose	≥4.0 MBq/kg	3	0.88 [0.78–0.97]	0.15	0.89 [0.77–1.00]	0.55
	<4.0 MBq/kg	3	0.86 [0.79–0.93]		0.91 [0.81–1.00]
ADC
China	yes	4	0.90 [0.85–0.95]	0.29	0.80 [0.69–0.90]	0.19
	no	3	0.82 [0.72–0.92]		0.81 [0.68–0.94]
No. of tumors	≥100	3	0.91 [0.88–0.95]	0.02	0.78 [0.67–0.89]	0.08
	<100	4	0.82 [0.75–0.88]		0.82 [0.71–0.93]
Max b value	1,000 s/mm2	4	0.91 [0.89–0.94]	0.05	0.79 [0.70–0.89]	0.04
	800 s/mm2	3	0.77 [0.70–0.84]		0.84 [0.68–0.95]
No. of imaging planes	3	3	0.87 [0.79–0.96]	0.07	0.82 [0.71–0.93]	0.29
	2	4	0.87 [0.80–0.94]		0.79 [0.68–0.90]
Slice thickness	6 mm	3	0.84 [0.78–0.95]	0.04	0.84 [0.75–0.93]	0.16
	5 mm	4	0.89 [0.80–0.95]		0.76 [0.64–0.87]
Vendor	GE	4	0.89 [0.84–0.95]	0.22	0.78 [0.67–0.89]	0.07
	Siemens	3	0.83 [0.74–0.93]		0.83 [0.72–0.94]

SUVmax, Maximum uptake value; ADC, Apparent diffusion coefficient.

p < 0.05 indicates that the comparison between groups is statistically significant and is indicated in bold.