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. 2022 Feb 9;9:770017. doi: 10.3389/fmed.2022.770017

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Copyright © 2022 Amorim, McGovern, Raposo, Khatiwada, Shen, Koentgen, Hold, Behary, El-Omar and Zekry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design and mouse body weight. (A) Study design. From five weeks of age, mice were given antibiotics in drinking water for 21 days. FMT of human donor stool sample (FMT group) or Saline (Sham group) was then orally administered weekly for 3 weeks, followed by a 5 week follow up period. Stool was collected every 3–4 days from day 0 until day 21, and then collected weekly until the completion of the experiment. F0–F3, FMT (Faecal Microbiota Transplant) weeks 0–3; E1–E5, Engraftment weeks 1–5. (B) Mouse body weight over the course of 12 weeks, with different treatments. Values shown are average ± SD (n =10 mice/group).