TABLE 2.
Univariate and multivariate analysis of training cohort.
| Characteristic | Univarite analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard rate (95%CI) | p value | Hazard rate (95%CI) | p value | |
| Age | ||||
| <65 | 1 | 1 | ||
| ≥65 | 1.63 (1.55–1.72) | <0.001* | 1.36 (1.28–1.43) | <0.001* |
| Race | ||||
| White | 1 | |||
| Black | 1.04 (0.97–1.12) | 0.311 | ||
| Other | 0.92 (0.84–1.01) | 0.076 | ||
| Sex | ||||
| Female | 1 | |||
| Male | 0.98 (0.93–1.03) | 0.358 | ||
| Primary_site | ||||
| Left_side_colon | 1 | 1 | ||
| Right_side_colon | 1.54 (1.46–1.63) | <0.001* | 1.29 (1.22–1.36) | <0.001* |
| Grade | ||||
| Grade_I | 1 | 1 | ||
| Grade_II | 1.05 (0.91–1.21) | 0.523 | 1.11 (0.97–1.28) | 0.13 |
| Grade_III | 1.64 (1.42–1.92) | <0.001* | 1.54 (1.33–1.78) | <0.001* |
| Grade_IV | 1.69 (1.42–2.12) | <0.001* | 1.55 (1.31–1.84) | <0.001* |
| Surgery | ||||
| Yes | 1 | 1 | ||
| No/Unknown | 1.99 (1.81–2.19) | <0.001* | 2.52 (2.28–2.84) | <0.001* |
| Radiation | ||||
| Yes | 1 | |||
| No/Unknown | 1.06 (0.93–1.21) | 0.4 | ||
| Chemotherapy | ||||
| Yes | 1 | 1 | ||
| No/Unknown | 2.91 (2.76–3.08) | <0.001* | 2.96 (2.79–3.13) | <0.001* |
| Marital_status | ||||
| Married | 1 | |||
| Unmarried | 1.06 (0.99–1.13) | 0.081 | ||
| AJCC_stage | ||||
| Iva | 1 | |||
| IVb | 1.56 (1.48–1.64) | <0.001* | ||
| T_stage | ||||
| T1+T2+T3 | 1 | 1 | ||
| T4 | 1.39 (1.31–1.46) | <0.001* | 1.34 (1.27–1.42) | <0.001* |
| N_stage | ||||
| N0+N1 | 1 | 1 | ||
| N2 | 1.36 (1.29–1.44) | <0.001* | 1.41 (1.34–1.51) | <0.001* |
| M_stage | ||||
| M1b | 1 | 1 | ||
| M1a | 1.56 (1.48–1.64) | <0.001* | 1.38 (1.33–1.46) | <0.001* |
| Bone_metastasis | ||||
| No | 1 | 1 | ||
| Yes | 1.95 (1.69–2.25) | <0.001* | 1.27 (1.12–1.48) | 0.0015* |
| Brain_metastasis | ||||
| No | 1 | 1 | ||
| Yes | 2.04 (1.6–2.59) | <0.001* | 1.67 (1.31–2.12) | <0.001* |
| Liver_metastasis | ||||
| No | 1 | 1 | ||
| Yes | 1.09 (1.02–1.15) | 0.006* | 1.51 (1.42–1.62) | <0.001* |
| Lung_metastasis | ||||
| No | 1 | 1 | ||
| Yes | 1.29 (1.2–1.38) | <0.001* | 1.14 (1.06–1.23) | <0.001* |
| Tumor_size | ||||
| <2 cm | 1 | 1 | ||
| 2–5 cm | 1.14 (0.94–1.39) | 0.183 | 1.11 (0.91–1.35) | 0.31 |
| 5–10 cm | 1.33 (1.09–1.63) | 0.004* | 1.18 (0.97–1.44) | 0.1 |
| >10 cm | 1.63 (1.3–2.04) | <0.001* | 1.22 (0.98–1.53) | 0.082 |
Bold values means P value less than 0.05.