TABLE 2.
Natural and synthetic polymeric fibers for SCI repair.
| Material | Animal | Injury type | Outcome | Reference |
|---|---|---|---|---|
| Collagen | Rat | Transection | Promoting axon regeneration and neurological recovery after SCI | Sun et al. (2019) |
| Rat | Hemisection | Decreasing of glial scarring and collagen deposition, and increasing of neurons | Breen et al. (2017) | |
| Mice | Transection | Connection of stumps in the transected spinal cord, differentiation of transplanted cells | Sugai et al. (2015) | |
| Gelatin | Rat | Transection | Reduction of cavity area, collagen deposition and inflammation | Lan et al. (2017b) |
| Mice | Hemisection | Reduction in necrosis, Infiltration of leukocytes, and apoptotic cells | Fan et al. (2018b) | |
| Chitosan | Rat | Hemisection | Promoting recovery of locomotor capacity and nerve transduction of the experimental rats | Wu et al. (2018) |
| PLA | Rat | Transection | Reducing the activation of astrocytes and increased axonal regeneration | Shu et al. (2019) |
| Rat | Transection | Robusting regeneration of vascularized central nervous system tissue | Hurtado et al. (2011) | |
| Rat | Hemisection | Supporting cell migration, proliferation and axonal regeneration | Cai et al. (2007) | |
| Rat | Transection | Promoting axonal growth and enhanced the functional recovery | Hurtado et al. (2006) | |
| PCL | Rat | Transection | Promoting axon regeneration in rat SCIs | Shahriari et al. (2017) |
| Rat | Hemisection | Restoring the continuity of the injured spinal cord and decreasing cavity formation | Terraf et al. (2017) | |
| Rat | Compression | Local application of MDL28170-loaded PCL film improved functional recovery by preserving survival of motor neurons after traumatic SCI | Shi et al. (2019) | |
| Rat | Transection | Promoting axonal growth and enhanced the functional recovery following SCI | Zhang et al. (2018) | |
| PLGA | Rat | Transection | Inducing short-term nerve regeneration and functional recovery following sciatic nerve transection in rats | dos Santos et al. (2019) |
| Rat | Hemisection | Promoting angiogenesis and neural regeneration in the injured area | Wen et al. (2016) | |
| Mice | Hemisection | Improving tissue regeneration, angiogenesis, and the recovery of locomotor function at the injury site | Gwak et al. (2016) |