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. 2021 Jul 17;19(3):346–357. doi: 10.1016/j.gpb.2021.03.008

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

scDPN provides reliable data for accurate scCNV detection

A. scCNV profiles of HeLa S3 cells obtained using the T2_P1 condition and the corresponding bulk-level profile from published data [34]. Colored dots correspond to inferred copy-number states; black lines indicate segment medians. B. scCNV profiles of the YH cell line obtained using the T2_P1 condition and the corresponding bulk-level profile from published data [35]. C. Representative single tumor cell CNV profile and the corresponding bulk tumor CNV profile from FACETS analysis of WES data from patient HCC01. For the bulk-level profile, the upper panel plots the corresponding integer (total and minor) copy number calls, while the lower panel shows the Cf-em profile that reveals both clonal and sub-clonal copy number events. scCNV, single-cell copy number variation; WES, whole-exome sequencing; HCC, hepatocellular carcinoma; Cf–em, estimated cellular fraction.