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. 2021 Sep 14;19(3):437–451. doi: 10.1016/j.gpb.2021.07.003

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© 2021 Beijing Institute of Genomics

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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DPs from PHFs and SHFs in the cashmere goat showed distinct gene expression profiles

A. Heatmap illustrating dynamic gene expression profiles during DP cell fate commitment. The gene expression pattern for each gene set is shown in the middle panel, and the top 4 enriched GO terms for each gene set are listed in the right panel. B. Pseudotime expression patterns of cell fate 1-enriched genes APOD and SOX18 and cell fate 2-enriched genes CENPW and TOP2A. Cells are color-coded according to the cell clusters as shown on the right. C. Volcano plot illustrating cell fates 1 and 2 as well as cell fate significantly enriched DEGs. D. Immunofluorescence analysis of BMP2, K15, VDR, and PCNA in PHFs and SHFs from E120 cashmere goat skin sections. Scale bar = 50 μm. DEG, differentially expressed gene; BMP2, bone morphogenetic protein 2; K15, keratin 15; VDR, vitamin D receptor; PCNA, proliferating cell nuclear antigen; DAPI, 4′,6-diamidino-2-phenylindole.