FIGURE 1.

Preparation and characterization of Poloxamer 407 and HA (PHa) hydrogels. (A) Schematic illustration of PHa hydrogel preparation. (B) The optical images of hydrogel sol–gel transition. (C) Storage modulus (G′) and loss modulus (G″) of hydrogel as a function of temperature. (D) The injectable and thermosensitive hydrogel rapidly form gel when injected into a hot plate at 37°C. (E) Morphologies of hydrogel observed by SEM. (F) Degradation rate of the PHa hydrogels in phosphate-buffered saline (PBS) at 37°C. (G) Release profile of icariin from the PHa hydrogels in PBS at 37°C (n = 3).