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. 2022 Feb 9;10:755260. doi: 10.3389/fbioe.2022.755260

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Copyright © 2022 Zhu, Ye, Cai, Li, Fan and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intra-articular injection of BMSCs incorporating PHa@I hydrogels inhibit inflammation and relieve pain in OA. (A,B) RT-qPCR analysis IL-10 and MMP-13 in cartilage. (C) Representative double immunofluorescence images of IL-10 and MMP-13. (D,E) Quantitative analysis of fluorescence intensity of IL-10 and MMP-13 in immunofluorescence staining. (F) Weight-bearing capacity was calculated by weight-bearing index (WBI). (G) Paw withdrawal threshold (PWT) was measured to test mechanical allodynia (*p < .05, **p < .01, and ***p < .001 compared with the PBS Group; ^# p < .05, ^## p < .01, and ^### p < .001 compared with the PHa@I Group; ^& p < .05 compared with the BMSC Group, n = 3).