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. 2022 Feb 9;10:822011. doi: 10.3389/fcell.2022.822011

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Copyright © 2022 Gu, Du, Zhao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Coexpressed genes and interactions of the m⁶A writer complex in HCC. (A) Volcano plots show differentially expressed genes related to the m⁶A writer complex in HCC (LinkedOmics). Heatmaps show the top 50 genes positively (B) and negatively (C) correlated with the m⁶A writer complex in HCC (LinkedOmics). Red indicates positively correlated genes, and blue/green indicates negatively correlated genes. (D) Heatmap shows mRNA level correlation between the m⁶A writer-complex components based on Pearson correlation coefficient. (E) Network for the m⁶A writer complex and its 10 most frequently altered neighboring genes. The red arrow indicates the most frequently altered neighboring genes.