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. 2022 Feb 9;10:822011. doi: 10.3389/fcell.2022.822011

FIGURE 8.

FIGURE 8

Protein–protein interactions (PPIs) and functional enrichment analysis of the m6A writer complex in HCC. (A) PPI network of the top 20 proteins related to the m6A writer complex in HCC (STRING). (B) Ten hub genes selected by Cytoscape from the PPI network. Red represents high degree value of the gene. Blue represents the hub genes except for the writer complex components. (C) Molecular function enrichment of the hub genes (Metascape). (D) Pathway enrichment of the hub genes (GSCALite). (E) Biological process enrichment of the hub genes (Metascape). (F) Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the writer complex and the top 200 coexpressed genes. (G) Network for GO and KEGG pathway enrichment.