Figure 5.

Regulatory mechanisms of embryo development revealed by the dark genes

A. Dynamic changes of human CSG-associated network composed of 6 CSGs and their 175 first-order neighboring DEGs for hESC-to-DEC transition. B. Dynamical changes of CSG-associated network for MEF-to-neuron transition during mouse embryo development. C. KEGG pathway enrichment analysis for the dark genes (on the right) and their 175 neighboring DEGs (on the left) in hESC-to-DEC process. D. Switching dynamics of DEGs before and after critical point induced by upstream dark genes. Dark genes refer to the genes with non-differential expression (P ≥ 0.05; t-test) but differential SGE value (P < 0.05). CSG, common signaling gene.