Figure 3.

miRNA–target interaction strength influences the noise reduction effect

A. The binding energy of all miRNA–mRNA pairs is ranked in ascending order. The endogenous miRNA target pool is indicated by wavy lines illustrating the affinity of the targets (red for high affinity, green for low affinity) and their relative abundances. B. Noise disparity between the target and non-target genes of the top 15 abundant miRNAs for strong (red) and weak (purple) interaction strength in mESCs. C. and D. AES score versus weak target pool abundance (C) and strong target pool abundance (D) across all miRNAs expressed in mESCs with strong miRNA–target interactions. Curves were fitted to $a+b{\log }_{10}(x+c)$, where $a$, $b$, and $c$ were determined by least-squares approximation. The fitted parameters are shown in Table S1.