Figure 4.

Gene expression noise is repressed by the miRNA coregulation subnetwork

A. AES score versus miRNA expression for miRNA individuals. B. Two examples of significant de-noising miRNA subnetworks for mESCs. Each node represents a miRNA species, and edges indicate the connection of miRNAs. Other significant de-noising miRNA subnetworks are shown in Table S2. C. AES score versus miRNA expression for miRNA subnetworks. D. AES score after subnetwork clustering versus the number of targets across all cluster miRNAs in mESCs. E. Similar points and fitting curve to those shown in (C) for target pool abundance. F. Pearson correlation coefficients between miRNA features (log₁₀ transformed) and AES scores for non-clustering, clustering by miRNA family, and clustering by network. Colors indicate different cell types. Curves in (A and C–E) were fitted to $a+b{\log }_{10}(x)$ where $a$ and $b$ were determined by least-squares approximation. The fitted parameters are shown in Table S3.