Supplementary figure 16.

The older miRNA families have shown a stronger effect in noise reduction than the younger miRNA. Box plots quantifying the ability of de-noising of old and young miRNAs. The unit of miRNA family age is millions of years ago (mya) and the age of the mouse miRNA family is between 37 and 1036 mya. The miRNA families whose age is less than the threshold are defined as the young miRNA families and the remaining miRNA families are defined as the old miRNA families. For different age thresholds, Mann–Whitney U test is used to quantify the difference in noise reduction between young and older miRNA families., and the age threshold is 100, 300, 500, 700 for subplots A, B, C, D respectively.