Table 2.
Treatment | ORR | DCR | OS | PFS | AEs grade ≥3 | SAEs |
---|---|---|---|---|---|---|
LFI | 0.34 | 0.42 | 0.41 | 0.42 | 0.27 | 0.20 |
LFIB | 0.57 | 0.89 | 0.51 | 0.46 | 0.35 | 0.23 |
LFIC | 0.67 | 0.49 | 0.57 | 0.49 | 0.41 | 0.37 |
LFIP | 0.85 | 0.59 | 0.61 | 0.54 | 0.48 | 0.42 |
LFIBP | 0.67 | 0.76 | 0.62 | 0.54 | 0.52 | |
LFO | 0.49 | 0.59 | 0.61 | 0.51 | 0.56 | 0.48 |
LFOB | 0.59 | 0.85 | 0.59 | 0.49 | 0.57 | 0.52 |
LFOC | 0.82 | 0.70 | 0.57 | 0.48 | 0.58 | 0.55 |
LFOP | 0.68 | 0.72 | 0.55 | 0.49 | 0.59 | 0.57 |
LFOI | 0.60 | 0.70 | 0.52 | 0.50 | ||
LFOIB | 0.82 | 0.93 | 0.50 | 0.52 | 0.59 | 0.59 |
LFOIC | 0.88 | |||||
LFOIP | 0.96 | 0.99 | 0.53 | |||
LF | 0.08 | 0.26 | 0.49 | 0.54 | 0.58 | |
LFB | 0.31 | 0.45 | 0.56 | |||
LFC | 0.17 | 0.50 | 0.54 | |||
LFBC | 0.35 | 0.70 | 0.59 | |||
LFP | 0.63 | 0.51 | 0.55 | 0.54 | 0.59 | |
CB | 0.31 | |||||
CI | 0.66 | 0.38 | ||||
CIB | 0.74 | 0.45 | ||||
IO | 0.39 | 0.36 | 0.51 | 0.55 | ||
IOB | 0.46 | 0.27 | 0.51 | 0.55 | ||
IP | 0.57 | 0.23 | ||||
FI | 0.27 | 0.36 | ||||
XB | 0.24 | 0.41 | 0.51 | 0.54 | 0.59 | |
XC | 0.73 | 0.36 | ||||
XI | 0.40 | 0.59 | 0.53 | |||
XIB | 0.49 | 0.73 | 0.51 | 0.53 | 0.52 | 0.59 |
XIC | 0.88 | 0.35 | ||||
XO | 0.36 | 0.53 | 0.48 | 0.51 | 0.51 | |
XOB | 0.43 | 0.55 | 0.38 | 0.47 | 0.49 | 0.58 |
XOC | 0.93 | 0.61 | ||||
XOBC | 0.48 | 0.54 | 0.26 | 0.43 | 0.46 | 0.57 |
X | 0.09 | 0.18 | 0.30 | 0.35 | 0.55 | |
C | 0.20 | 0.11 | ||||
I | 0.09 | 0.13 | ||||
O | 0.06 | 0.18 | 0.40 | |||
P | 0.26 | 0.14 |
ORR, overall response rate; DCR, disease control rate; OS, overall survival; PFS, progression-free survival; AEs, adverse events; SAEs, serious adverse events; X, capecitabine; B, bevacizumab; C, cetuximab; F, 5-fluorouracil; I, irinotecan; L, leucovorin; O, oxaliplatin; P, panitumumab.