Figure 4.

Roles of the FGFR family in breast cancer. Schematic of breast cancer extracellular environment (from figure 1) and breast cancer epithelial cells (from figures 1 and 2). The asterisks indicate the three main FGFR isoforms with a critical role in breast cancer progression. The text in burgundy indicates the mechanisms underlying FGFR roles in breast cancer, including secretion of FGFs, interactions with proteins of the extracellular matrix, regulation of vasculature during angiogenesis, crosstalk with HER2, regulation of signalling, metabolism and transcription, changes in intracellular localization, and genomic alterations, as described in the main text. The black lines on the ‘FGF’ text indicate the lack of available information on the role of those specific FGFs in breast cancer.